Best is a relative term that has to many variables.
there is no silenced handgun in resident evil 4 its just an untrue rumor
ump45 silenced
It all depends on what your style is. Do you run around and shoot anything that moves? Desert Eagle or Magnum then. If you are more of a stealth person use M9 or Usp silenced. Always use tactical knife or akimbo though.
mp7 silenced fmgs akimbo and silenced slight of hand assassin pro dead silence pro
The Brady Handgun Violence Prevention Act
UMP.45 is defiantly the best but the MP5K works well
I believe I've remembered: Inception.
i like the galil silenced it works for me(gotton dogs many of times), some people like famas silenced you should try them, but mostly its not the best gun that wins maches its how you use them.
Open
Glock
Depends on application but I can give you the guns that give the most damage of each type:::Assault Rifle-FAL:::Light Machine Gun-RPD (silenced does equal damage as unsilenced):::Submachine Gun-UMP45 (silenced does equal damage as unsilenced):::Sniper Rifle-Barrett .50 cal:::Machine Pistol-M93 Raffika:::Shotgun-Ranger:::Handgun-.44 Magnum (desert eagle is equal in damage but has more recoil):::Launchers-Javelin:::
Best left to a gunsmith