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You do not need to use a comma directly after the word "in." It is a preposition, so it will be used in a prepositional phrase. If that phrase is at the beginning of a sentence, then you may need to put a comma after the phrase.

EX: In the wee hours of the morning, Donald took his dog for a stroll through the cow pasture. In the pasture, they saw a cow.

However, this has more to do with where the prepositional phrase is placed, not that the phrase uses "in." Look at how commas are not necessary if the sentence is reworded:

Donald took his dog for a stroll through the cow pasture in the wee hours of the morning. They saw a cow in the pasture.

Answer

The above answer is usually true, but not always. There ARE some sentences in which a comma is used after the word "in." For example:

She doesn't have a pot to pee in, but she's out buying clothes like she's Paris Hilton.

Everybody else wanted to go in, but she refused, on the grounds that the club "looked seedy."

There was a line of people outside waiting to get in, but she took her time opening up the store anyway.

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15y ago

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