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Both can mean "surrender" or "acquiesce" but there are semantic differences in their use.
To give up can mean to surrender (admit defeat) or quit (stop trying) or yield (also transitive as in to give up something: to relinquish it, especially to someone else).
To give in is to yield to another plan, arguments, or opinions; to cease opposition; to accept especially grudgingly.
(* there is a related separate meaning: to break or fail under pressure)
Examples:
After several failures, I decided to give up trying to complete the experiment. (quit)
The police convinced the criminal to give up, and took him into custody. (surrender)
The student had to give up his parking spot when the parking lot was remodeled. (relinquish)
The coach finally convinced me to give in and accept his decision. (stop opposition)
The congressman would not give in to pressure to change his vote. (yield, here refusal to yield)
* If the wall supports give in, the ceiling of the gym could collapse.
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