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"You and I" will act as the subject of the sentence (the subject does the action). In simpler sentences, this will be found at the beginning of the sentence.

Example: You and I have to go to the store tomorrow.

"You and me" will act as the object of the sentence (the object "receives" the action). You will usually find it after the verb.

Example: The Johnsons invited you and me to their party tomorrow. (Granted, it would be simpler to say "invited us")

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15y ago

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