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The grizzly is a race of the brown bear, and the brown and polar bears are very closely related. The two species diverged around 100,000 years ago.

Bears, in the taxonomic family of Ursidae, split off from other Carnivorans about 38 million years ago. Then the Ursinae subfamily originated around 4.2 million years ago. According to both fossil and DNA evidence, the polar bear split from the grouping of the brown bear, Ursus arctos, roughly 200,000 years ago. This is thought to have happened due to their isolation during a period of glaciation in the Pleistocene period.

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