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Big dogs have a lot of hip and joint problems. The bigger the dog the harder it is on their joints. When people get older they stop jumping around and carrying on...most dogs don't.Also it is hard on their backs. The longer the dog (great dane for example) the more space between his front and back legs. Also, there are a lot of big breed dogs that are prone to neurological problems too. Its a shame, I love big dogs. Also having to maintain a larger body is harder on all parts of the body, like their heart and other organs. They are the ones who usually get Arthritis and have intestinal problems. There is just so much more strain on their body. Little dogs don't have such a large body to maintain and usually have less issues having to do with their organs and their bones.

2nd Answer:

Some of the larger breeds are prone to cancer and heart problems, such as Great Danes tend to have heart problems, Bullmastiffs tend to have cancer, etc. It breaks your heart to own a large breed as they pass on way too soon.

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