Does a great Dane's run differ from a typical dog?

Answer 1

Yes, after the dog is about a year old. Before that, the legs are too delicate. If it's a year or two old, you can't keep up with it unless it is on leash. An adult can probably run further and faster than you.

Answer 2

Actually No. But you may find it a little bit different than usual dogs because of their sheer size and bulk.