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Once a cat has caught and eaten a mouse, if the cat is going to catch anything from the mouse, it is a bit too late for vaccination... vaccination is to prevent disease, and by the time you have the cat to the vet for the booster shot, if it is infected, the infection is already past the point at which vaccination will help.

If you expect that your cat will be catching mice, vaccination with periodic boosters is a good idea, as mice do carry diseases that cats can catch.

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