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No one really knows for sure, but one study noted an increased DHT level and DHT:testosterone ratio in men taking creatine. Testosterone is converted to DHT by 5alpha-reductase, and high DHT levels and DHT:testosterone ratio have been associated with male pattern balding. Propecia, which is used for male pattern balding, is a 5alpha-reductase inhibitor which is supposed to prevent further balding by decreasing conversion of testosterone to DHT.

This effect is probably only likely to occur in people who are genetically susceptible to male pattern baldness however.

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