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Most female dogs come into season for the first time between 6 and 12 months, although some larger breeds delay until as late as 2 years. Like most mammals, the age that a bitch first comes into season is mostly a function of her current body weight as a proportion of her body weight when fully mature. They then experience estrus about every seven months until old age. Female dogs do not experience menopause, although their cycles will become irregular and fertility becomes unpredictable as they become older. Dogs over around 7 or 8 years are usually considered no longer appropriate for breeding, but can still remain fertile.

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