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The most obvious signs are changes in appetite and activity. They may lose weight (you need to weigh your pig regularly - every day if you suspect it's ill), they may have crusties around the eyes, sneeze, cough, squeal while peeing - it depends on the illness. Any change is an indication something is wrong.
If you're not sure whether your pig is sick or healthy take it to an exotics vet to find out for certain.

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15y ago

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