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Yes, if you have ever heard of a liger or a tigon, they are the result of a female lion and a male tiger. Ligers are much bigger than normal tigers. Actually, a liger embryo is so large that a female tiger is too small to carry it, so the female in the equation has to be a lioness and, therefore the male would be a tiger. Although a lion and tiger can mate to create a liger, ligers cannot mate together to create other ligers. It's kind of like how mules can't mate to create other mules.

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