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Yes, theoretically, but if it's eating a healthy diet, including lots of hay, then a rabbit won't over eat enough cardboard to make itself ill. Lots of rabbits like to chew and shred cardboard, and if a rabbit eats some (even if it seems like a lot), that's fine -- it counts as roughage (fibre -- a good thing!). We're talking plain cardboard, here -- unbleached, minimal colours, no slick glossy paper or labels, no staples or tape. (See the link below.)

But if a rabbit is really hungry because it isn't eating the right diet, or if a rabbit is really disturbed for some other reason (maybe if it's being neglected or not cared for properly), then it could theoretically eat too much cardboard, make itself sick, and eventually die if doesn't get to a vet.

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