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Tender hepatosplenomegaly can be caused by a variety of conditions, including Infectious Diseases (such as viral hepatitis or mononucleosis), hematologic disorders (like leukemia or lymphoma), and metabolic disorders (such as Wilson's disease). Inflammatory conditions, such as autoimmune hepatitis or sarcoidosis, can also lead to enlargement and tenderness of the liver and spleen. Additionally, congestive heart failure or cirrhosis may contribute to this condition. It is important to evaluate the underlying cause for appropriate management.

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6d ago

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