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Pregnant Mare Serum Gonadotrophin (PMSG), also known as

Equine Chorionic Gonadotrophin, is secreted by the endometrial

cups of the pregnant mare. The endometrial cup is a placentaassociated

structure derived from the foetus which forms

several weeks into gestation and is destroyed immunologically several months later.

The hormone PMSG is found in the blood of the pregnant mare in significant

amounts between 40 and 100 days of gestation in the average mare, peaking at

approximately 60 days gestation. After 100 days reliable results are no longer

produced due to the destruction of the endometrial cups.

This test determines the presence of PMSG molecules in the maternal circulation.

However if the foetus dies after the development of the endometrial cups, the

endometrial cups remain and are eliminated in the same time frame as they would be

in a viable pregnancy. This can lead to false positive results.

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