Mrs in Portuguese is "Dona".
Dona (Portuguese)
na Portuguese title of address equivalent to Mrsor Madam: placed before a name to indicate respect
In Portuguese, you would address Mr. as "Sr." (Senhor) and Mrs. as "Sra." (Senhora) on an envelope. For example, if addressing a married couple, you would write "Sr. e Sra. [Last Name]." If you are addressing them individually, you would write "Sr. [First Name] [Last Name]" for Mr. and "Sra. [First Name] [Last Name]" for Mrs.
Mrs. Greta & Mr. Neal Featherston, Jr.
mr ans miss or.... for mrs is madame. mr ans miss or.... for mrs is madame.
I would address it to Mr and Mrs David Keys. For the salutation I would use Dear Mr and Mrs Keys.
Mr. and Mrs. John Smith III
Mr. and Mrs. James Bitner III
As Mr & Mrs.
The abbreviation in Italian for Mr. is "Sig." which stands for "Signore," and for Mrs. is "Sig.ra" which stands for "Signora." These abbreviations are commonly used in formal contexts in Italian language to address or refer to a man or a woman respectively.
Mr. used to be acceptable to address a household by just using the last name, e.g. "Mr. Jones". In modern times, it is typically to use "Mr. and Mrs. Jones" or "Mr. and Mrs. Timothy Jones".
The proper way to address that letter would be "Mr. and Mrs. John Doe."
You can address it to Mr and Mrs. Smith. You could address it is as the Smith Family. Or you could address it as Mr. Smith and Family.
Mr. & Mrs. <lastname>