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In short, no-one knows. A common story is that during the time of the Bubonic Plague (of which sneezing was an early symptom) people would say "bless you" in case the sneezer had the plague - the practise having started in 590 by Pope Gregory I.

However, it's known that people have said "Bless-you" after a sneeze since at least 77AD, so the plague explanation seems unlikely.

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15y ago

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