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it depends on how you use the word chance in a sentence. If you're trying to combine 2 sentences into 1,and if the first sentence ends with chance, then that's when you use a comma.

You could say, or write:

I wonder what the chance is of rain today?

Don't take a chance on the weather being fine.

Is there a chance, do you think, that it will be sunny?

A word doesn't necessarily require a comma under most circumstances; the use of punctuation depends on context.

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13y ago

What else can I help you with?