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No lack of energy only decreases the air in your lungs which is bad because you can suffocate and die but in a way... good because your burning off calories and working out (Dont work out to mch or you'll end up in the hospital)

Prolonged lack of oxygen, perhaps. Every cell in your body requires oxygen to function properly; deprive them of that essential nutrient, and eventually you start shutting down. No oxygen means that your mitochondrial electron transport chain in your cells (which makes ATP, e.g. energy that you need to live) completely shuts down. I'm not sure about retardation, but lack of oxygen could potentially cause multiple negative side-affects.

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