0
NSAIDS can induce two forms of acute renal failure:
1. Haemodynamically mediated
2. Acute interstitial nephritis
Haemodynamically mediated: Renal prostaglandins are vasodilators, but do not play a major role in renal haemodynamics in healthy patients and the basal rate is relatively low. When there is underlying disease, such as heart failure, cirrhosis or volume depletion, the levels of hormone: PGs are increased and they act as vasodilators to ensure adequate renal flow and GFR. Inhibition of prostaglandin synthesis with an NSAID in such patients can lead to reversible renal ischemia, a ↓ in GFR and acute renal failure.
NSAIDs also produce interstitial nephritis with or without nephrotic syndrome secondary to minimal change disease. Although this presents as acute renal failure, it can progress in some cases to chronic renal failure.
NSAIDs increase the risk of developing heart failure in patients with a history of HTN, DM or renal failure, particularly in the first month of use.
What else can I help you with?
State 2 causes of renal failure?
Most cases of renal failure can be attributed to high blood pressure and diabetes. There are other conditions which can cause renal failure, but it isn't common.
Can kidney stones cause chronic renal failure?
Yes
Can reflux nephropathy cause chronic renal failure?
Yes
Can High blood pressure cause chronic renal failure?
Yes
Can insulin dependent Diabetes mellitus cause chronic renal failure?
Yes
Do renal angiomyolipomas cause kidney failure or mean that you are already in kidney failure?
It is a very unlikely cause of kidney failure(if it is large and bilateral or affect the only existing kidney) .
Can tonsillitis cause renal failure?
No. Tonsilittis is an infection in the lymphatic system and is no more liley to cause kidney failure than having the common cold.
What are the medical implications of renal failure?
decreased filtration and decreased secretion combine to cause increased plasma potassium. Hyperkalemia is the most significant and life-threatening complication of renal failure
Is renal failure and renal insufficiency the same?
yes,Renal failure or kidney failure (formerly called renal insufficiency) describes a medical condition in which thekidneys fail to adequately filter toxins and waste products from the blood. The two forms are acute (acute kidney injury) and chronic (chronic kidney disease); a number of other diseases or health problems may cause either form of renal failure to occur.
Can non-insulin dependent Diabetes mellitus cause chronic renal failure?
Yes
What did Alfred Hitchcock die of?
He died of Kidney failure while in his sleep in 1980.
Can Glomerulonephritis cause chronic renal failure?
Yes, glomerulonephritis can lead to chronic renal failure if left untreated or if it causes extensive damage to the kidneys over time. It is important to manage and treat glomerulonephritis promptly to prevent progression to chronic renal failure.
