How does Schildkraut's theory of depression compare with more recent ideas on the aetiology of the condition?

Answer 1

Schildkraut's theory of depression, primarily focused on the role of neurotransmitters, particularly the deficiency of norepinephrine and serotonin, laid the groundwork for understanding the biological underpinnings of the disorder. In contrast, more recent ideas on the aetiology of depression acknowledge a multifactorial approach that incorporates genetic, environmental, psychological, and social factors alongside neurobiological aspects. Current models emphasize the complex interplay between these elements, suggesting that depression results from a combination of neurochemical imbalances and psychosocial stressors rather than a singular cause. This shift reflects a broader understanding of mental health, moving towards integrative treatment approaches.