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§ Methoxyflurane → methoxydifluoroacetic acid (MDFA) <chlorination>

§ Methoxyflurane → fluoride + dichloroacetic acid <O-demethylation>

§ MDFA degrades to fluoride

§ Experiments have shown that it is probably the combination of fluoride and dichloroacetic acid which causes nephrotoxicity.

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15y ago

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