Yes, this is true: "Doctors in Germany say a patient appears to have been cured of HIV by a bone marrow transplant from a donor who had a genetic resistance to the virus. The researchers in Berlin said the man, who suffered from leukaemia and HIV, had shown no sign of either disease since the transplant two years ago. But they stressed it was an unusual case which needed further investigation. Experts said the result may boost interest in gene therapy for HIV. Berlin's Charite clinic said the 42-year-old patient was an American living in Berlin, but the man has not been identified. "
The Doctors - 2008 Can It Be Cured was released on: USA: 2 December 2009
DefinitionA bone marrow transplant delivers healthy bone marrow stem cells into the patient. It replaces bone marrow that is either not working properly or has been destroyed (ablated) by chemotherapy or radiation.Alternative NamesTransplant - bone marrow; Stem cell transplant; Hematopoietic stem cell transplant; Reduced intensity, nonmyeloablative transplant; Mini transplant; Allogenic bone marrow transplant; Autologous bone marrow transplant; Umbilical cord blood transplantDescriptionBone marrow is the soft, fatty tissue inside your bones. Stem cells are immature cells in the bone marrow that give rise to all of your blood cells. Your blood is made of:Red blood cells (which carry oxygen to your tissues)White blood cells (which fight infection)Platelets (which help your blood clot)In a bone marrow transplant, you will receive healthy stem cells after your own bone marrow has been destroyed.There are three kinds of bone marrow transplants:Autologous bone marrow transplant. "Auto" means "self." Stem cells are taken from the patient before the patient gets chemotherapy or radiation treatment. When chemotherapy or radiation is done, the patient gets their stem cells back. This is called a "rescue" transplant. It allows the patient to receive high doses of chemotherapy and radiation.Allogeneic bone marrow transplant. "Allo" means "other." Stem cells come from another person, who is called a donor. Donor stem cells come from the donor's bone marrow or their blood. Most times, a donor must have the same genetic typing as the patient, so that their blood "matches" the patient's. Special blood tests will tell whether a possible donor is a good match for the patient. A patient's brothers and sisters have the highest chance of being a good match (25% chance for each full sibling), but sometimes parents and children of the patient and other relatives may be matches. Donors who are not related to the patient may be found through national bone marrow registries.Umbilical cord blood transplant. Stem cells are taken from an umbilical cord right after delivery of an infant. The stem cells are tested, typed, counted, and frozen until they are needed for a transplant. Umbilical cord blood requires less stringent matching because the stems cells are so immature.Many patients get high doses of chemotherapy, radiation, or both, before the bone marrow transplant. This is called ablative (or myeloablative) treatment. It kills any cancer cells that might remain, and it makes room in the bone marrow for the new stem cells to grow.Today, some patients are getting less chemotherapy and radiation before their transplant. This is called a reduced intensity (nonmyeloablative) or "mini" transplant.After the patient gets chemotherapy and radiation, a doctor will do the stem cell transplant. The patient gets the stem cells through a tube called a central venous catheter. The process is similar to receiving a blood transfusion. The cells go right into the bloodstream and find their own way to the bone marrow. Usually, no surgery is required.Donors may have minor surgery to collect their bone marrow and stem cells. For a bone marrow harvest, they will be unconscious and pain-free (under general anesthesia) while their bone marrow is removed from their hip bone. In many cases however, stem cells can be collected right from the blood. The donor will first receive injections for a few days.When receiving stem cells, a patient may have these symptoms:PainChillsFeverHivesChest painDrop in blood pressureShortness of breathNauseaFlushingHeadacheFunny taste in the mouthWhy the Procedure Is PerformedBone marrow or stem cell transplant may be recommended for:Certain cancers, such as leukemia, lymphoma, and multiple myelomaIllnesses where the bone marrow does not produce the right kind of or enough cells. Some of these are: Sickle cell anemiaAplastic anemiaThalassemiaCongenital neutropeniaSevere immunodeficiency syndromesRescue transplant to replace bone marrow, when treatment for cancer has destroyed a patient's bone marrowRisksAll bone marrow transplants have risks. The risk is higher or lower depending on many factors. Some of these factors are:What disease you haveWhat type of treatment (chemotherapy, radiation) you have before the bone marrow transplantHow old you areHow healthy you are when you have your transplantHow good a match your donor isWhat type of bone marrow transplant patient you are having (autologous, allogeneic, or umbilical cord blood)Complications you may have are:Infections: These may be very serious.Bleeding: This can happen in the lungs, the intestines, brain, and any other part of the body.AnemiaDiarrhea, nausea, and vomitingPainSevere mucositis (inflammation and soreness) in the mouth, throat, esophagus, and stomachDamage to the kidneys, liver, lungs, and heartCataractsEarly menopauseGraft failure, which means that the new cells do not settle into the body and start producing stem cellsGraft-versus-host disease: This is when your donor's cells attack your own body. In the first few months after the transplant, symptoms may be a skin rash, diarrhea, or abnormal liver tests. Later, symptoms may be dry eyes or mouth, tightness of the skin, scarring in the lungs, chronic diarrhea, and other problems.Children who get transplants may have delayed growth.Before the ProcedureYour health care provider will ask you about your health record and do a physical exam. You will also have many tests before your treatment begins.Your doctor or nurse should discuss the emotional stress of having a bone marrow transplant. You may want to meet with a mental health counselor talk. Talking with your family and children to help them understand and prepare is important.You will need to make plans for when you have the transplant. Items to consider are:Household choresCare of petsPayment of billsBank or financial statementsSchedules and care for your childrenInsurance coverageArranging medical leave from workAdvanced care directivesYou may need to find housing for yourself or your family near the hospital.Before the transplant, one or two catheters are inserted into larger blood vessels, usually in the neck, for you to receive treatments, fluids, and sometimes nutrition.After the ProcedureBone marrow transplant patients usually go to medical centers, or hospitals, that specialize in this treatment. Most times the patient will stay in a bone marrow transplant unit in the center to limit their chance of getting an infection.Some patients who get autologous or non-myeloablative allogeneic transplants do not have to stay in the hospital or medical center. They can get the transplant as an outpatient.Some patients may have part of their autologous or allogeneic transplant done as an outpatient.Most patients will be in the hospital for 4 to 6 weeks. During this time, you will be isolated and watched closely because of the increased risk of infection.While you are in the hospital, these things may happen:Close monitoring of your blood and vital signsYou may have to take antibiotics, antifungal medications, and antivrial medications to prevent or treat infection.You may need many blood transfusions.You may have to stay in a room where special things are done to prevent infection.You may get calories and proteins through an intravenous (IV) line until you can eat on your own, and until your diarrhea, nausea, or mouth sores have cleared up.You may have to take medicine to prevent graft-versus-host disease.Outlook (Prognosis)How well you do after transplant greatly depends on these things:What type of bone marrow transplant you hadHow well your donor's cells match yoursWhat type of cancer or illness you haveYour age and overall healthWhat type of chemotherapy or radiation therapy you had before your transplantWhat kind of complications happened after the transplantYour genetic make-upPossible results of a bone marrow transplant are complete cure of the illness being treated, a partial cure, or death. Death may be caused by complications of the bone marrow transplant or because the transplant did not work to treat the illness.If the transplant works, you can go back to most of your normal activities as soon as you feel well enough. Most times it takes up to 12 months to recover fully.ReferencesBishop MR, Pavletic SZ. Hematopoietic stem cell transplantation. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKena WG, eds. Clinical Oncology. 4th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 32.Vose JM, Pavletic SZ. Hematopoietic stem cell transplantation. In: Goldman L, Ausiello D. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 184.
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Fire Study was created in 2008-03.
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Orthodox Study Bible was created in 2008.
DefinitionTransplantation is a procedure done to replace one of your organs with a healthy one from someone else. It is a complex, long-term process of which the actual surgery is only one element.A wide range of experts will help you prepare for the procedure, and to make sure you are comfortable before, during, and after surgery.InformationTransplant surgery is typically done to replace a diseased body part with a healthy one.SOLID ORGAN TRANSPLANTSAuto islet cell transplant is done after a person has their pancreas removed due to chronic pancreatitis. The procedure isolates insulin-producing cells from the pancreas and returns them to the patient's body.Corneal transplant replaces a damaged or diseased cornea. The corner is the clear tissue on the front of the eye that helps focus light on the retina. It is the part of the eye on which a contact lens rests.Heart transplant is an option for someone with congestive heart failure that has not responded to medical treatment.Intestinal transplant is an option for patients with short bowel or short gut syndrome or advanced liver disease, or who must receive all nutrients through a feeding line. See: Total parenteral nutrition(TPN)Kidney transplant is an option for someone with chronic renal failure. It may be done with a kidney-pancreas transplantdeceased-donor transplantLiver transplant may be the only option for someone with liver disease leading to liver failure.Lung transplantmay replace one or both lungs. It may be the only option for someone with lung disease who has not gotten better using other medicines and therapies, and whose survival is predicted at less than 2 years.BLOOD/BONE TRANSPLANTS (STEM CELL TRANSPLANTS)A stem cell transplant may be needed if you have a disease that damages the cells in the bone marrow or if your received high doses of chemotherapy or radiation.Depending on the type of transplant, your procedure may be called a bone marrow transplant, a cord blood transplant, or a peripheral blood stem cell transplant. All three use stem cells, which are immature cells that give rise to specific cell types. Stem cell transplants are similar to blood transfusions and generally do not require surgery.There are two different types these transplants:Autologous transplants use the patient's own blood cells or bone marrow.Allogeneic transplants use a donor's blood cells or bone marrow. A syngeneic allogenic transplant uses cells or bone marrow from the patient's identical twin.For more information, see: Bone marrow transplantTHE TRANSPLANT SERVICES TEAMThe transplant services team includes carefully selected experts, including:Surgeons that specialize in performing organ transplantsOther medical doctorsRadiologists and medical imaging technologistsNursesInfectious disease expertsPhysical therapistsPsychiatrists, psychologists, and other counselorsSocial workersNutritionists and dieticiansThis list may not be all-inclusiveBEFORE A TRANSPLANTYou will have a complete medical exam to identify and treat all medical problems, such as kidney and heart disease.The transplant team will evaluate the patient and review their medical history to determine if the patient meets the criteria for organ transplantation. Most types of organ transplants have guidelines detailing what type of patient is most likely to benefit from a transplant and will be able to manage the challenging process.If the transplant team believes you are a good candidate for a transplant, you will be put on a national waiting list. Your place on a waiting list is based on a number of factors, which depend on the specific type of transplant you are receiving.Once on the waiting list, the search for a matching donor begins. Types of donors depend on your specific transplant but include:A living related donor is someone who related to the recipient, such as a parent, sibling, or child.A living unrelated donor is a person such as a friend or spouse. After donating the organ, the donors can live a normal, healthy life. Donors can live a normal, healthy life.A deceased donor is someone who has recently died. The heart, liver, kidneys, lungs, intestines, and pancreas are life saving organs that can be recovered from an organ donor.You should identify family, friends, or other caregivers who can offer help and support during and after the transplant process.You will also want to prepare your home to make it comfortable for when you return after being released from the hospital.AFTER A TRANSPLANTHow long you stay in the hospital depends on the specific type of transplant that you have. However, you will be seen daily by the transplant services team.Your transplant services coordinators will arrange for your discharge and discuss with you plans for care at home, transportation to clinic visits, and housing, if necessary.You will be told how to take care of yourself after the transplant. This will include information aboutMedicationsHow often you need to visit the doctor or clinicWhat daily activities are allowed or off limitsAfter leaving the hospital you will return to where you lived.You will have periodic follow-ups with the transplant team, as well as your primary care doctor and any other specialists that may be recommended. The transplant services team is always available to answer any of questions that you may have.ReferencesHerman M, Keaveny AP. Organ Transplantation. In: Walsh D, Caraceni AT, Fainsinger R, et al, eds. Palliative Medicine. 1st ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 183.Bishop MR, Pavletic SZ. Hematopoietic stem cell transplantation. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKena WG, eds. Clinical Oncology. 4th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 32.American Cancer Society. What is a Bone Marrow or Stem Cell Transplant? Accessed March 16, 2010.Organdonor.gov. Types of Organ Donation. Accessed March 16, 2010.
The Doctors - 2008 Carmen Face Transplant Reveal Joy Bauer Food Cures and Family Fitness Challenge 5-141 was released on: USA: 1 May 2013
Batman Black and White - 2008 Case Study 1-4 was released on: USA: 8 December 2008