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Both RSD and CFS are real physical disorders. RSD's main characteristic is pain while CFS's main characteristic is debilitating exhaustion. Both seem to have connections with the central nervous system. For CFS, there is no one particular test that can diagnose the condition, so many suffer from being labled a hypochondriac or their sympotms are blamed on depression. But most CFS sufferers who are given MRI's show abnormalities, white spots, on the brain. Others are often found to have heart and blood pressure abnormalities that were not present before the onset of CFS. It is not uncommon for people with CFS to also have other disorders along with CFS and it is possible to have both.

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