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Edward Jenner's research methods primarily involved observational studies and controlled experimentation. He famously conducted an experiment in 1796 by inoculating a young boy, James Phipps, with material taken from a cowpox sore, observing that the boy developed immunity to smallpox. Jenner meticulously documented his findings, comparing the effects of cowpox and smallpox vaccinations. His method laid the groundwork for the development of the smallpox vaccine and the field of immunology.

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