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It blocks the voltage-gated Na+ channels.

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13y ago

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Why is numbness experienced after eating puffer fish?

TTX (the poison in pufferfish) inhibits neurons that transmit sensory information to the brain. Since TTX prevents the generation of action potentials in sensory nerves, the ability of the neurons to transmit sensory information will be inhibited. This loss of sensory information would be experienced as a "numbness" in areas exposed to the toxin.


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Why are fewer action potentials redorded at recording electrodes R2 when TTX is applied between R1 and R2?

TTX blocks voltage-gated sodium channels, which are necessary for action potential initiation and propagation. When TTX is applied, sodium influx is prevented, leading to a decrease in action potentials recorded at electrode R2 due to the inability of neurons to generate and transmit action potentials.


What does TTX do to voltage-gated Na channels?

Tetrodotoxin (TTX) is a natural inhibitor and blocks single sodium channels in an all-or-none manner.


Why are fewer action potentials recorded at R2 when TTX is aaplied between R1 and R2?

TTX will block the response at R1 but have no effect at R2


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They both decrease action potential duration, but TTX is the only one that decreases the maximum rate of depolarization.


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Why are fewer action potentials recorded at R2 when TTX is applied between R1 and R2?

When tetrodotoxin (TTX) is applied between R1 and R2, it blocks voltage-gated sodium channels, preventing the influx of sodium ions necessary for depolarization during an action potential. As a result, the action potentials generated at R1 cannot propagate to R2, leading to fewer or no action potentials being recorded at R2. This illustrates the critical role of sodium channels in the transmission of electrical signals along neurons.