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treatment for creatine kinase

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14y ago

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Where is the active site of creatine kinase?

The active site of creatine kinase is located within the cleft between the N-terminal and C-terminal domains of the enzyme. This is where the substrates, creatine and ATP, bind and undergo the catalytic reaction to produce phosphocreatine and ADP.


Does cholesterol medication cause creatine kinase?

Cholesterol medication can increase the level of creatine kinase. Hence it is highly recommended to keep an eye on the level of creatine kinase (CK) if one is taking cholesterol medication. High level of CK can affect the muscles including the heart and kidneys. I am on cholesterol medication for ten years and only found out about the high level of CK after constant pain in the body muscles. My CK was three times the normal value and hence doctor had to change the type of cholesterol medication. They are many other factors that can cause the increase in CK but definitely those people on cholesterol medication are highly recommended to get their CK tested once in a while.


What is creatine kinase?

Creatine Kinase is actually a type of blood test. It checks for raised blood levels of certain brain and muscle enzyme proteins. Raised levels may indicate several things including stroke, heart attack, brain tumors, hypothyroidism, muscular dystrophy, and many other things. It depends on which enzyme is elevated as to what it may be indicating.


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How is creatine kinase produced in the body?

Creatine kinase (CK) is produced primarily in muscle, brain, and heart tissues, where it plays a crucial role in energy metabolism. It catalyzes the conversion of creatine and ATP (adenosine triphosphate) into phosphocreatine and ADP (adenosine diphosphate), facilitating the rapid regeneration of ATP during high-energy demands. The enzyme is synthesized from specific genes, with different isoforms (such as CK-MM in muscle and CK-MB in heart) produced depending on the tissue type. CK levels can be measured in the blood, and elevated levels often indicate muscle damage or stress.