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Many people were against Edward Jenner's work on vaccination due to a combination of skepticism and fear. Some viewed the practice of inoculating with cowpox as unnatural and feared potential side effects, while others were concerned about the implications of using animal matter in human medicine. Additionally, the scientific understanding of disease and immunology was limited at the time, leading to widespread distrust of new medical practices. This resistance was also fueled by social and cultural beliefs that favored traditional remedies over innovative approaches.

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