Zycodin is a brand name for a medication that typically contains a combination of hydrocodone and acetaminophen. It is used to relieve moderate to severe pain. Hydrocodone is an opioid analgesic, while acetaminophen is a non-opioid pain reliever that enhances the pain-relieving effects of hydrocodone. Due to its opioid content, Zycodin has potential for misuse and dependency, so it is prescribed with caution.