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What is the half life of Abciximab?
30min
Structure activity relationship of antiplatelet drugs?
More correctly it is called antiplatelet aggregation drugs (also called antithrombotic drugs) that include aspirin, clopidogrel, abciximab (monoclonal antibodies) and GPII/ IIIA receptors antagonists etc. Each drug has its own way and mechanism of action. It depends upon chemical structure of drug and site of action. Aspirin blocks aggregation by inhibiting cycloxygenase that produce thromboxane A2 that causes platelet aggregation. Clopidogrel acts as antagonist to P2Y2 receptors present on platelets required for their aggregation. You can check for further details. Umar Mujahid Pharm.D u.mujahid@yahoo.com
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