It is a word that starts with the letter C and it currently ends with the letter N. However the definition of the word is unknown by Marcus Bazil, but hey sh*t happens thank you for reading this and waisting 10 seconds of your life.
CK7, or cytokeratin 7, is a protein that is part of the cytoskeletal structure in epithelial cells. Tumors that express CK7 are typically associated with certain types of cancers, such as those originating in the lung, ovary, and breast. The presence of CK7 can help pathologists in diagnosing specific tumors and determining their origin, as different cancers have distinct patterns of cytokeratin expression.
Human Retinal Pigment Epithelial Cells (HRPEpiC) are isolated from human retina. HRPEpiC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HRPEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, cytokeratin-19 and fibronectin. HRPEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi.
Melanocytes do not produce the intermediate filament cytokeratin. This becomes important medically when distinguishing between pruritic, erythematous ulcers of the vulva. Extramammary Paget's Disease will be distinguised from a melanoma by keratin, PAS, and S100 staining.
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Positive CK7 refers to the presence of cytokeratin 7 (CK7) protein in tissue samples, typically analyzed through immunohistochemistry. CK7 is a type of intermediate filament protein expressed in various epithelial tissues, and its positivity can help in the diagnosis and classification of certain tumors. For example, CK7 positivity is often associated with adenocarcinomas of the lung, breast, and ovary, among others, aiding in differentiating between various types of cancers. Its expression pattern can provide important insights into the tumor's origin and behavior.