Microchimerism involves injecting tiny samples of the donors tissues many months prior to the transplant. With very little damage (a needle prick), the immune system only slightly attacks the injected tissues. Soon the immune system sees no damage in the body, but still sees the foreign tissue. Over time, the immune system gets used to the donors tissues and starts seeing it as being a part of the body, and considers it an exception in the things it should attack. Once it is confirmed that the immune system is no longer attacking the donor tissue, the transplant can occur with little to no need for immuno-suppressants.