The English Civil War took a great affect on them because they had to decide
whether to support the king or the Parliament.
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Germany and Italy took part in the Spanish Civil War, testing their soldiers and weapons.
African Americans were allowed to fight with the rest of the Armed Forces.
No, there have been many civil wars in various countries around the world, but World War 2 was not a civil war.
There were many negative effects of the US Civil War. To note one huge negative effect was the loss of over 620,000 lives because Americans could not reach a compromise on issues that divided the nation. The loss of lives has to be the major negative effect.
I am not being facetious: The biggest effect of World War I was World War II.