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In some regards, though it would be very difficult to draw the line between "truth" and "fiction".

Charlie Kaufman really was the screenwriter for Being John Malcovich (and Adaptation). The BJM actors shown in the film are the real actors. Susan is also a real person and she did write a book called "The Orchid Theif". I believe that La Roche exists in real life too but I'm not sure. Donald Kaufman doesn't. The guy who runs the screenplay seminar does.

I believe Charlie really did go through a similar struggle trying to "adapt" the orchid thief into a movie and the way he came up with a lot of "Adaptation" was similar to what we see in the film. I don't know to what extent that's true though. Some of the Hollywood characters in the film (his agent etc.) could be real people too.

However, I think we can safely assume that the last 3rd of the movie is almost completely fictional.

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