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  1. Take I-40 EAST to I-55 NORTH to BLYTHEVILLE and St. Louis at EXIT 277.
  2. Take I-55 NORTH to Perryville. The exit for Perryville is EXIT 129.

The route is around 325 miles and will take approx. 5 hours.

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Q: Quickest route from Little Rock Arkansas to perryville mo?
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