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Ran is a small GTPase that plays a crucial role in nucleocytoplasmic transport, regulating the transport of proteins and RNA across the nuclear envelope. It is involved in the export of proteins from the nucleus to the cytoplasm and the import of proteins into the nucleus. Additionally, Ran is essential in cell cycle regulation and mitosis, particularly in the formation of the mitotic spindle. Its activity is driven by the binding and hydrolysis of GTP, which enables the conformational changes necessary for its functions.

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3w ago

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