To simplify the question, let's assume you don't have to take off or avoid other traffic; you start in the air over San Francisco, and you're the only thing in the sky so you can take the most direct route.
In that case, you'd be flying about ten degrees south of due east.
Which ever direction you choose I think it best to go straight as opposed to all ziggy zag (because that works out to be farther), Also look at a globe and take the SHORT straight way because you could also take the opposite way but it is longer (the world being roundish and all. And consider this while you are at it: If you start out going north and just keep going you will wind up going south eventually BUT if you go west and just keep going you will just keep on going west which is good because you don't get tricked into going the opposite way all the sudden like if you went North. Another good thing is if you time it right and travel fast enough going west it will stay stay daylight for you the whole way which is good because traveling at night can be dangerous.
Personally however I would worry my little head over it for a minute, Why I'd just buy tickets for an airline and then let them worry about it directions with all their computers and compass GPS thingies.
Hope this helps! Have a nice trip if you are going there.
It would have to kind of be in a south-western direction.
It depends on where you're traveling to. Your question is highly inaccurate. next time, make it more accurate.
west and partly south
Northwest.
South East
East
The movie Bed Knobs and Broomsticks has a flying and time traveling bed (that includes a flying mattress).
6 hours flying
About 9 hours if your flying with Malev airlines and have no-connections.
Usually when you fly from New York to San Francisco the flight takes longer in elapsed time than the trip from San Francisco to New York. Flying from east to west in the Northern Hemisphere usually means flying into the wind, while flying west to east gives a tail wind. Also, the trip flying west may seem shorter because of the three-hour difference between the two locations: 4:44 New York (Eastern) = 1:44 San Francisco (Pacific)
It's not necessary, but that's the shortest way, and that's what all the airlines do.
southeast Southeast
southeast
You'd be traveling South East, SE, since Miami, Florida is east and south of San Francisco.
southeast
west
Roughly southeast
Cardinal direction is North (intermediate direction is north by northwest)
about 10-12 hours depending on which direction you are flying in.
north
Southeast
4 to 4.5 hours depending on which direction you are flying.
You are flying west (start at north, and work your way around clockwise, 90 degrees for every quarter of a circle)