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Sheldon never strips for cancer on The Big Bang Theory. However in the episode The Pants Alternative, Sheldon becomes nervous about having to give an acceptance speech for an award and Penny gives him some champagne. He then gets up to receive the award, tells some off-color jokes then proceeds to remove his pants, which is later revealed by a YouTube video the morning after.

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Q: What episode of big bang theory does sheldon strip for cancer?
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