Itachi had an unknown illness that weakened him. Whatever illness this was, it was worsened by his abilities to a point where he could no longer sustain life (by using Mangekyo Sharingan and Susano'o). Before battling Sasuke, he also had been drained from giving a power to Naruto, making him exceptionally weaker for that battle. There are many theories about the illness he had, ranging from lung cancer to Tuberculosis, and even the chance it could be some random unknown illness caused by Susano'o or from his bloodline, or even from depression. He contracted this illness at some time after killing the Uchiha Clan.
June 9th
chapter 367
Yes, on chapters 487-488
yes, but if you think about itachis eyes there equal
He gets very angry with Konoha, and plans to destroy it. To the ground.
June 9th
GEMINI
chapter 367
def,up,jump,att
Yes, on chapters 487-488
The Leaf Village, ad Most of All.... His brother, Sasuke
yes, but if you think about itachis eyes there equal
Can be translated into scarlet/red/vermilion.
He gets very angry with Konoha, and plans to destroy it. To the ground.
Itachi doesn't have a uncle as far as I know. If he did, Itachi probably killed him too.
Yes he does and now uchiha madara gave him itachis eyes so he will have eternal mangekyu sharngan
Link Below - that is the real mangyeou sharingan of sasuke uchiha