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Katherine Potrev was born in the 1400's. Because she got pregnant, when giving birth, her father disowned her and took the baby, therefore there's the first child in the blood line. Now 1900's Isobel Flemming was born. She got pregnant with John Gilbert, therefore creating Elena. Now because Katerina is a vampire, she's been alive for the last 500 years.

ANWSER: Katherine is the maternal great x 25 grandmother.

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Q: What is the relationship of Katherine and Elana on Vampire Diaries?
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