What is the saddest desperate housewives episode ever?

Answer 1

In Season 2, An episode where they took Gaby's and Carlos's Baby away was pretty sad.

Also the end part of season 3 episode 7 where Lynette had a dream after the hostage situation in the store.

The scene where Gaby was releasing the balloons for her baby and she was forced to confront her grief-- heartbreaking.

Answer 2

The First ever episode was called the 'pilot'.

Episode Synphosis:

One day in the suburb of Wisteria Lane, residents are shaken up by the sudden suicide of Mary Alice Young. At her wake, her four close friends and the main characters, Bree Van de Kamp, Lynette Scavo, Susan Mayer and Gabrielle Solis, are introduced. All of them lead seemingly perfect lives, trying to keep their problems from each other. Susan and Edie Britt fight over the new neighborhood resident and plumber Mike Delfino. Lynette's children cause a ruckus in the Youngs' pool, putting her in an embarrassing position. Gabrielle is having an affair with her teenage gardener John Rowland, because she is neglected and treated condescendingly by her busy husband, Carlos. Bree's husband Rex collapses from an allergic reaction at a diner, shortly after asking her for a divorce. Susan accidentally burns Edie's house down, after going over to see if she was with Mike. While the ladies put away Mary Alice's belongings, they discover a mysterious blackmail note addressed to her, leaving them to wonder what she had done.