That depends on what you term a "major city" . I would say that Bahia Blanca, a city of 300,000 fits that description, but others may differ.
No. The oldest city in South America, also found in Perú, is Caral.
South America's highest capital city is La Paz in Bolivia
Windsor, Ontario The most southern city in Canada is Windsor, Ontario located on the Detroit River.
rosario
The country is Chile, and the capital is Santiago.
A major city in South America is Brazil.
Santiago, Chile
South America is as far as you can get to Antarctica, Antarctica is the only landmass south of it. Tierra Del Fuego is as low as you can get in South America and Buenos Aires I Think lies the furthest south
south america,
dover
detroit
capetown
Xoconocho
The capital that is farthest south is Kampala
The farthest point on earth from Taiwan's capital Taipei is Asunción, the capital of Paraguay in South America.
Ushuaia, Argentina is the southernmost city in world
Corpus Christi, TX