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While both systems communicate to many parts of the body, and control aspects of its functioning, the nervous system acts quickly, and the endocrine system acts more slowly.

Both systems use chemical messengers to communicate from cells to other cells in the body. The endocrine system uses chemicals called hormones, and the nervous system uses chemicals called neurotransmitters.

The endocrine system releases hormones into the blood stream, which transports them throughout the body where they act on cells anywhere in the body when they reach cells which have the corresponding receptors.

The nervous system releases neurotransmitters from a neuron into a very small gap called a synapse where it diffuses very quickly to another neuron.

It takes much longer for a hormone to reach its distant target by being moved around the body by the blood stream than it takes neurotransmitters to move between neurons and for a consequently generated action potential impulse to be moved along a neurons axon to its destination.

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