The yellow eyed demon killed their father.
Their last names are Winchester.
Sam and Dean's father is named John Winchester.
Lucifer.
The character Sam in Supernatural is related to the character Dean but the actors Jared Padalecki and Jensen Ackles are not real-life brothers. so yeah there not biologicaly related
Jared Padalecki
Their last names are Winchester.
Both Sam and Dean were born in Lawrence, Kansas. Sam was six months old when their mother was killed by Azazel, and their father John became a hunter out of revenge.
Sam and Dean's father is named John Winchester.
Jack and Sam.
In the TV show Supernatural, Jessica Moore was killed by a demon named Azazel as part of his plan to manipulate Sam Winchester into becoming a hunter. Her death becomes a catalyst for the events that follow throughout the series.
Jack is 13 and Sam is 10.
Lucifer.
Dean and Sam's car in "Supernatural" was a 1967 Chevy Impala. =)
Jared Padalecki plays Sam Winchester.
The character Sam in Supernatural is related to the character Dean but the actors Jared Padalecki and Jensen Ackles are not real-life brothers. so yeah there not biologicaly related
1975 he published Fast Sam, Cool Clyde and Stuff,
Jared Padalecki