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meg and stewie (Family Guy may deny this) were based off of Meg and Charels Wallace from A Wrinkle in Time. The daughter thinks she's ugly and etc., and the son is a genius. Look it up. (not the movie- the movie was bad)

-- It should be noted that the above answer is opinion based only. There is no solid evidence, i.e. interviews with the Seth MacFarlane or cast, that proves this. After all, in Stewie's case, Seth has stated Stewie was based on British actor Rex Harrison.

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Q: Who were Family Guy's Meg and Stewie based on?
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