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When a female horse and a male donkey mate, you get a mule, but two mules can’t mate to create another mule because of their chromosomal makeup.

A mule gets 32 horse chromosomes from its mother and 31 donkey chromosomes from its father. Mules are almost always sterile because those chromosomes don’t match up well enough to create egg or sperm cells.

I say “almost always” because there have been a few extremely rare instances of female mules reproducing with a male donkey or horse. But those are so rare they’re often called “miracles,” and there have been no documented instances of a male mule fathering any offspring. So, as far as we know, two mules cannot reproduce.

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Willy Quitzon

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5y ago

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