Why is o-bromoacetanilide is removed from p-isomer?

Answer 1

O-bromoacetanilide is removed from the p-isomer due to the differences in polarity and solubility between the isomers during purification processes, such as recrystallization or chromatography. The p-isomer, which has the bromo group in the para position, is generally more stable and less polar than the o-isomer, allowing for easier separation based on these physical properties. Additionally, the steric hindrance and electronic effects in the ortho position can lead to different reactivity, facilitating the removal of the o-isomer.