Why were the Amerindian ended up as the biggest losers?

Answer 1

Many Indains died out. There are several answers to the question-when the colonists arrived they brought with them more than themselves they brought dieseases. Through contact and the poor hygenie of the colonists, the Indians became sick and perished. It is estimated that 90% of Indians died from old world sicknesses. The colonists would sometimes give the Indians blankets that had the germs on them that caused the sickness giving them the sickness. The Indians usually had tension with the settlers over matters like land and food. The Indians were used as slaves sometimes and died due to neglect. -Roundrupert

Answer 2

Because the Europeans came to the Americas to convert the Indians religious beliefs and because most of them didn't want to abide by that, the Europeans killed them.