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Imipramine has been used for a number of years for thr treatment of bedwetting in patients over the age of 6, though the primary indication is for use as an antidepressant. It is generally used after possible organic causes have been ruled out. The precise mechanism of action of imipramine is not definitely known. It may affect the muscles of the bladder, or it may have some effect on the hormone that causes the kidneys to release urine antidiuretic hormone (ADH), or it may work by causing the child to sleep more lightly. The mode of action of the drug in controlling childhood enuresis is thought to be apart from its antidepressant effect.

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