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The most negative change during the Jackson era was the implementation of the Indian Removal Act of 1830, which led to the forced relocation of thousands of Native Americans from their ancestral lands in the Southeast to designated territories west of the Mississippi River. This policy resulted in the tragic Trail of Tears, where many indigenous people suffered from disease, starvation, and exhaustion, leading to thousands of deaths. Additionally, Jackson's presidency marked a period of increased political divisiveness and the entrenchment of a more aggressive form of populism that often marginalized minority voices and interests.

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